WASHINGTON (AP) — An influential federal advisory panel has overwhelmingly rejected a plan to give Pfizer booster shots against COVID-19 to most Americans, but it endorsed the extra doses for those who are 65 or older or run a high risk of severe disease.

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The twin votes Friday represented a heavy blow to the Biden administration’s sweeping effort to shore up nearly all Americans’ protection amid the spread of the highly contagious delta variant.

The decision was made by a committee of outside experts who advise the Food and Drug Administration.